Parental Deprivation Induces N-Methyl-D-Aspartate-Receptor Upregulation in Limbic Brain Areas ofOctodon degus: Protective Role of the Maternal Call

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Parental Deprivation Induces N-Methyl-D-Aspartate-Receptor Upregulation in Limbic Brain Areas of Octodon degus: Protective Role of the Maternal Call

An optimal coordination between parents and their offspring involves a sequence of reciprocal behaviors to ensure the adequate care of the young, which is critical for a healthy physical, emotional, and social development. Parental deprivation, particularly an impaired child-mother attachment, induces lasting changes in emotional as well as in cognitive capacities in later life. We assessed in ...

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Background Anti-N-methyl- d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune neurological disorder that usually occurs as a paraneoplastic syndrome and is particularly associated with ovarian teratoma. Standard therapy for severe cases is not established and the prognosis in patients who do not respond to first-line treatment is poor. Case Report An 11-year-old boy complained ps...

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Objective(s): -methyl-D-aspartate NMDA receptor (NMDAR) and aquaporin 4 (AQP4) are involved in the molecular cascade of edema after traumatic brain injury (TBI) and are potential targets of studies in pharmacology and medicine. However, their association and interactions are still unknown.Materials and Methods: We established a rat TBI model in this study. The cellular distribution patterns of ...

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The effect of morphine dependence on expression of hippocampal N-methyl-D-aspartate receptor subunits in male rats

Introduction: N-methyl-D-aspartate (NMDA) receptors play a pivotal role in the development of tolerance and physical dependence to opiates. Activation of NMDA receptors involves the induction of long term potentiation (LTP) in hippocampus. Our previous study suggested that chronic oral administration of morphine enhanced NMDA dependent LTP in the CA1 area of hippocampal slices of rats. The p...

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Excitotoxicity is a major mechanism of neuronal damage in cerebral ischemia and is mediated largely by neuronal N-methyl-D-aspartate receptors (NMDAR). This review presents the structural and functional alterations in NMDAR after an ischemic insult, including the antagonistic roles different NMDAR sub-types play in the post-ischemic period. By elucidating these molecular changes and the effects...

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ژورنال

عنوان ژورنال: Neural Plasticity

سال: 2000

ISSN: 2090-5904,1687-5443

DOI: 10.1155/np.2000.233